2007

Ann. Rheum. Dis.  66(2):1765-1771.  Modulation of Established Murine Collagen-induced Arthritis by a Single Inoculation of Short- term Lipopolysaccharide-stimulated Dendritic Cells.

Eur Cytokine Netw. 18(3):127-135. Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis.

Molecular Immunology. Echinococcus granulosus Calreticulin: Molecular Characterization and Hydatid Cyst Localization. In press.

Research in Veterinary Science.   Assessment of the IgG index in dogs by indirect immunoenzimatic assays as diagnostic tool for inflammatory diseases of central nervous system.  In press

Molecular Immunology. 44:2115-2123  Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human monocytes and human lymphocyte cell lines in vitro.

Comp. Biochem. Physiol. A Mol. Integr. Physiol. 146:601–620.   Mode of action of Natural and Synthetic Drugs Against Trypanosoma cruzi  and their Interaction with the Mammalian Host.

Reprod Fertil Dev. 19(5):634-40. Effect of oestradiol and progesterone on the instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate the kinetic effect of oestradiol.

Biol Res. 40:97-112. Toll- like receptors are key participants in immune responses.

J Immunol. 178(11):6949-6957. Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells.

Eur Cytokine Netw. 18(2):31-38. Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic cells into a tolerogenic phenotype.

Cytokine Growth Factor Rev. 18(1-2):171-182. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape.

Invest Ophthalmol Vis Sci. 48(3):1219-1227.  Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy.

2006

Scand J Rheumatol. 35(6):435-40. Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis.

Immunobiology. 211(1-2):127-36. The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines.

Eur Cytokine Netw. 17(2):125-130. NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in a group of Chilean patients with Inflammatory Bowel Disease.

J Pharmacol Exp Ther. 318(1):59-67. Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis.

Immunobiology. 211(1-2):75-84. Could single nucleotide polymorphisms (SNPs) affecting to the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?

Immunobiology. 211:11-27.  Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and cellular immune responses in mice.

Prostaglandins Other Lipid Mediat. 80(3-4):155-64. 17-beta-Estradiol upregulates COX-2 in the rat oviduct.

2005

Rev Med Chil. 133(9):1089-95. The influence of -238 and -308 TNF alpha polymorphisms on the pathogenesis and response to treatment in rheumatoid arthritis.

Rev Med Chil. 133(8):969-76. Emergent therapies for rheumatoid arthritis.

Clin Exp Immunol. 142(3):555-568. Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients.

J Rheumatol. 32:2116-2124. Anti- Tumor Necrosis Factor-a therapy augments Dipeptidyl Peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis.

Biol Res. 38:7-12. Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy.

Biol Res. 38:187-195. F(ab`)2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first complement component.

Trends Parasitol. 21:169- 174. Trypanosoma cruzi  Calreticulin in the Parasite / Host Relationship: Modulation of the Complement System and Angiogenesis.

Mol Biochem Parasitol. 140:133-140. An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis.

2004

J Immunol. 173(3):1731-1737. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells.

Eur Cytokine Netw. 15(4):364-370. The -308 polymorphism in the promoter region of tumor necrosis factor-alpha (TNF) gene and ex vivo lipopolysaccharide-induced TNF expression in patients with aggressive periodontitis.

Scand J Rheumatol. 33:228-232. TNF levels and influence of -308 TNF promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis.

Mol Immunol. 40:1279-1291. Role of Calreticulin from Parasites in its Interaction with Vertebrate Hosts.

Parasitol Res. 92:375-379. Development of Immunometric Assays to Asses the Alimentary Behavior of Mepraia spinolai.

J Immunol. 172:3042-3050. The Classical Activation Pathway of the Human Complement System is Specificaly Inhibited by Calreticulin from Trypanosoma cruzi.

2003

Rev Med Chil. 131(12):1445-53.  New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies.

Eur Cytokine Netw. 14(3):128-133. Ex vivo lipopolysaccharide (LPS)-induced TNF, IL-1, IL-6 and PGE2 secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis.

Vet Res. 34:177-184. An anti-human recombinant tumor necrosis factor alpha (TNF) monoclonal antibody recognizes an epitope in feline TNF.

Rheumatology. 42:308-313. The -308 polymorphism in the tumor necrosis factor gene promoter region and ex - vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in chilean patients with rheumatoid arthritis.

2002

Rev Med Chil. 130(9):1043-1050. Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease.

Br J Cancer. 87(4):414-422. Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker.

Eur Cytokine Netw. 13(4):1-6. In vitro TNF Alpha Producing Capacity of Lipopolysaccharide Stimulated Monocytes from Women with Polycystic Ovary Syndrome.

Inmunología.  21(3):156-168.  Parasite Calreticulin: Possible Roles in the Parasite / Host Interface.

2001

Biol Res. 34:237-241. Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population.

J Med Entomol. 38:303-307. Blood Host Sources of Mepraia spinolai (Hemiptera, Reduviidae), wild Vector of Chagas Disease in Chile.

Eur Cytokyne Netw. 12:105-110. Daily production of human tumor necrosis factor in lipopolysaccharide (LPS)-stimulated ex vivo blood culture assays.

2000

Am J Trop Med Hyg. 63:306-312. Tc45, a dimorphic Trypanosoma cruzi immunogen with variable chromosomal localization, is calreticulin.

Int J Parasitol. 30:981-984. Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes.

Acta Trop. 75:291-300. Development of an immunoenzymatic  assay   for the detection  of   human antibodies against Trypanosoma cruzi calreticulin, an immunodominant antigen.

1999

Med Oncol. 16(2):86-94. Interleukin-10: A cytokine used by tumors to escape immunosurveillance.

1997

Int J Parasitol. 27:1429-1432. Immunodiagnosis of fasciolosis in horses and pigs using western blot.

Acta Trop. 63:159-166. Recognition of an immunogenetically  selected Trypanosoma cruzi antigen by  seropositive  chagasic human  sera.

Parasitología al Día  2:79-82.  Inmunidad anti Protozoaria.  Destilado de hechos recientes.

Archivos de Medicina Veterinaria  29(1): 133-139.  Anticuerpos Policlonales Anti-Inmunoglobulinas de Salmón. Herramientas potenciales para Diagnóstico.